The molecular shape of poly(propylenimine) dendrimer amphiphiles has a profound effect on their self assembly.

TitleThe molecular shape of poly(propylenimine) dendrimer amphiphiles has a profound effect on their self assembly.
Publication TypeJournal Article
Year of Publication2010
AuthorsChooi KWai, Gray AI, Tetley L, Fan Y, Uchegbu IF
JournalLangmuir
Volume26
Issue4
Pagination2301-16
Date Published2010 Feb 16
ISSN1520-5827
KeywordsDendrimers, Micelles, Molecular Structure, Particle Size, Polypropylenes, Surface Properties, Surface-Active Agents, Thermodynamics
Abstract

The shape of dendrimer amphiphiles has an unexpected effect on their self-assembly. A series of diaminobutane poly(propylenimine) generation 3 dendrimer (DAB-dendr-(NH(2))(16)) amphiphiles has been synthesized, bearing an average of five (PD5), three (PD3) and one (PD1) palmitoyl group(s) per dendrimer molecule. Additionally DAB-dendr-(NH(2))(16) was derivatized with a layer of poly(ethylene glycol) (PEG, degree of polymerization = 12) groups and conjugated to an average of 1 palmitoyl group at the PEG end (PPD1). A final amphiphile resulted from the conjugation of DAB-dendr-(NH(2))(16) with 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-succinimidylpropionate (DSPE-PEG(3400)-SPA), i.e.: DPD5 (with 4 DSPE-PEG arms). The critical micellar concentration in aqueous media followed the trend: DPD5

DOI10.1021/la9027282
Alternate JournalLangmuir
PubMed ID19860445